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Dr. BABY CHAKRAPANI P S

Assistant Professor

Department of Biotechnology

Cochin University of Science and Technology
Kochi - 682022, Kerala, India

E-mail-

chakrapani@cusat.ac.in



BRIEF BIO
Dr. Baby Chakrapani P. S. is currently working as an Assistant Professor at Department of Biotechnology, Cochin University of Science and Technology. Before joining the Department of Botechnology, he was working as a Post-Doctoral Researcher at Van Andel Research Institute, Michigan, USA (2013-2015). He also worked as a Research Fellow at Department of Pharmacology, National University of Singapore (NUS), Singapore during the period 2011-2013. He received Ph.D. degree in the area of Neural Stem Cell Research from Centre for Neuroscience, University of Freiburg, Germany in 2011 and the M.Sc. degree in Biotechnology from Cochin University of Science and Technology in 2004. He also worked as a Research Associate at Indian Institute of Technology (IIT), Kanpur, India during 2004-2005. His academic interest and research focus includes Neuroscience, Stem Cell Research, Neurodegeneration, Microbiota-Gut-Brain axis and Neuroregenerative therapies.

JOURNAL PUBLICATIONS (RECENT) [TOTAL PUBLICATIONS : 34]
  • Microbial consortia-derived cellulose biomaterial: Synthesis, characterization, and utility in neural tissue regeneration, International Journal of Biological Macromolecules, Elsevier 2024

  • Fluorescence bioimaging applications of europium-doped strontium aluminate nanoparticles, Ceramics International, Elsevier 2024

  • Neurological, psychological, psychosocial complications of long-COVID and their management, Neurological Sciences, Springer International Publishing 2024

  • Luminescent Tb3+/Sm3+ co-doped hydroxyapatite nanoparticles as an imaging probe in N2a cells, Spectrochimica Acta, Elsevier 2024

  • Transcriptomic analysis of CNTF-treated mouse subventricular zone-derived neurosphere culture reveals key transcription factor genes related to adult neurogenesis, Heliyon, Elsevier Vol. 10, 2024

  • Protection by nano-encapsulated Bacoside A and Bacopaside I in seizure alleviation and improvement in sleep-in vitro and in vivo evidences, Molecular neurobiology, Springer US Vol. 61, 2024

  • Exploring the short-term influence of a proprietary oil extract of black cumin (Nigella sativa) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study, Frontiers in Nutrition, Frontiers 2024

  • An easy and cost-effective method for the isolation and culturing of Neural Stem/ Progenitor cells from the Subventricular (SVZ) and Dentate Gyrus (DG) of Adult Mouse Brain, Journal of Neuroscience Methods, Elsevier 2024

  • Unravelling the Parkinson’s puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies, Experimental Brain Research, Springer 2023

  • Protection by Nano-Encapsulated Bacoside A and Bacopaside I in Seizure Alleviation and Improvement in Sleep- In Vitro and In Vivo Evidences, Molecular Neurobiology, Springer 2023

  • CONFERENCE PUBLICATIONS (RECENT) [TOTAL PUBLICATIONS : 9]
  • Differentiation and Characterization of Peripheral Blood Mononuclear Cell (PBMNC) derived Nestin positive cells cultured on fibrin matrix, 7th Asian Biomaterials Congress (TERMIS-AP + ABMC7 2019), October 2019. Brisbane, Australia, 2019

  • A Novel Conducting Hydrogel Tissue Engineering Scaffold for Neuroregeneration., 7th Asian Biomaterials Congress (TERMIS-AP + ABMC7 2019), October 2019. Brisbane, Australia, 2019

  • A Novel Conducting Hydrogel Tissue Engineering Scaffold with Enhanced Mechanical Stability for Neuroregeneration, Cell and Stem cell Biology conference" August 2018, Singapore, 2018

  • Isolation and Characterisation of blood derived stem cells expressing neuronal markers., XXXVI Annual Conference of Indian Academy of Neurosciences, October 2018, Varanasi, India , 2018

  • Role of gp-130 Associated Cytokine (CNTF) in the Proliferation and Differentiation of Neural Stem Precursor Cells from SVZ Adult Mice, XXXVI Annual Conference of Indian Academy of Neurosciences, October 2018, Varanasi, India, 2018

  • Potential of novel mTOT modulator to treat dyskinesia in a 6-OHDA rat model of Parkinson’s disease (PD) , World Parkinson Congress 2013, Montreal , 2013

  • CNTF inhibits proliferation and promotes early differentiation of progenitor cells in neural stem cell cultures from the adult subventricular zone, 10th Göttingen Meeting of the German Neuroscience Society, 2013, 2013

  • CNTF promotes the maintenance of neural stem cells in cultures from the adult mouse subventricular zone , 10th Göttingen Meeting of the German Neuroscience Society, 2013 , 2013

  • Optogenetic investigations of the functional integration of neural stem cells in an animal model of Parkinson's disease. , 8th FENS Forum 2012, Barcelona , 2012

  • AWARDS AND HONOURS
  • 'Young Investigators Programme in Biotechnology" from Kerala State Council for Science Technology and Envronment (KSCSTE), in the year 2017

  • Member of Committee of Green Protocol in the University from Haritha Kerala Mission-Govt of Kerala, in the year 2018

  • Member of Board of Studies in Biological and Chemical Sciences from CUSAT, in the year 2018

  • Member of Board of Studies in Zoology from Christ College, Iringalakuda, Kerala, in the year 2019

  • Member of Board of Studies in Biotechnology from St.Berchman's College, Kottayam, Kerala, in the year 2018

  • Nodal Officer from CUSAT, Haritha Kerala Mission, Govt. of Kerala., in the year 2018

  • Member of Project Implementation Group from APEX Committee: Inter University Centre for Nanomaterials and Devices (IUCNMD)"CUSAT, in the year 2019

  • Member of Programme Implementation Group from Promotion of University Research and Scientific Excellence (PURSE)-Programme Implementation Group", CUSAT, in the year 2016

  • Secretary from Dept of Biotechnology, CUSAT, in the year 2018

  • Life member from Indian Academy of Neurosciences, in the year 2020

  • Research Guide from CUSAT, in the year 2019

  • Joint Secretary from Society for Biotechnologists (India), in the year 2017

  • RESEARCH PROJECTS
  • "KSCSTE YIPB project -Title: "The role of gp130-associated cytokines in the regulation of adult Neural stem Cell (NSC) proliferation and differentiation" " (KSCSTE- 2016 --0001 )

  • ""Exploring the Human Gut Microbiome And Metabolome In Health and Parkinson Disease-A Window To the Gut-Microbiota-Brain Axis Alterations in Parkinsons Disease"" (ICMR- 2019 --0001 )

  • "Development of bioavailable formulations of phytonutrients with cognitive and memory enhancing properties for the management of neurovegetative conditions and traumatic brain injury. (PI)" (CUSATECH Foundation- 2020 -2023 , Total outlay Rs.5000000)

  • ""University-Start-up Grant - Title: "Generation and characterization of dopaminergic neurons from peripheral blood derived mononuclear cells"" (CUSAT- 2017 --0001 )

  • "Biocompatible 3D Scaffolding through Femtosecond Laser Photo- polymerization for Tissue Engineering and Regenerative Medicine " (Govt of Kerala (Chancellors Award grant)- -0001 --0001 , Total outlay Rs.40000000)

  • PATENT
  • A MEDIA FORMULATION AND A METHOD FOR TRANS-DIFFERENTIATION OF BLOOD PROGENITOR CELLS INTO DOPAMINERGIC NEURONAL LINEAGE - Granted,2022